Palladium-Catalyzed Modification Of Nucleosides, Nucleotides And Oligonucleotides

Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. This valuable work provides some of the key synthetic protocols for these reactions and is the latest volume in the Latest Trends in Palladium Chemistry series, edited by Professor Anant Kapdi and Professor Debabrata Maiti. Most of the research in the field of antiviral agents has centered on the use of modified nucleosides that have exhibited promising activity. It has therefore become a necessity to have a comprehensive database of the catalytic reactions that could provide direct access to such synthetically and commercially viable molecules. Additionally, applications of chemically modified nucleotides as lab reagents and utility of synthetic oligonucleotides as therapeutics have further enhanced the need for a comprehensive overview of the field. Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compounds Includes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalization Highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist

• | Author: Anant R. Kapdi, Debabrata Maiti, Yogesh S. Sanghvi
• | Publisher: Elsevier
• | Publication Date: Jun 06, 2018
• | Number of Pages: 358 pages
• | Language: English
• | Binding: Paperback/Science
• | ISBN-10: 0128112921
• | ISBN-13: 9780128112922