Overview
Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.
- | Author: Peter De Wulf
- | Publisher: Springer
- | Publication Date: Nov 11, 2008
- | Number of Pages: 516 pages
- | Binding: Hardback or Cased Book
- | ISBN-10: 0387690735
- | ISBN-13: 9780387690735
