Overview

1. Neuroanatomy of dopaminergic system in the human brain.- 2. Radioligands for PET studies of D2-receptors: butyrophenone and ergot derivatives.- 3. Radioligands for dopamine receptor PET studies: benzamides and ligands for dopamine D-1 receptors.- 4. Monoamine precursors in PET research - biochemical issues and functional significance.- 5. Quantitation problems in positron emission tomography (PET) as applied to the kinetic analysis of the striatum dopamine data.- 6. Investigation of the dopamine system with positron emission tomography: general issues in modeling.- 7. Modelisation: application to the D2 receptors.- 8. [18F] Fluorodopa uptake in brain.- 9. Dopamine reuptake sites: the issues.- 10. Movement disorders: the clinical issues.- 11. Non-human primate models of dopamine system disorders: understanding neurodegenerative diseases and testing new therapeutic strategies.- 12. The dopamine system and mental disorders: clinical and psychopharmacological overview.- 13. D2 dopamine receptors and schizophrenia.- 14. The assessment of central D2-dopanvne receptor occupancy with positron emission tomography in long-term medicated schizophrenic patients.- 15. Measurement of dopamine receptor occupancy: clinical issues.