Overview
A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses.
- | Author: Charles J. Hackett
- | Publisher: Humana
- | Publication Date: Dec 09, 2010
- | Number of Pages: 284 pages
- | Binding: Paperback or Softback
- | ISBN-10: 1617372404
- | ISBN-13: 9781617372407
