Overview
A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.
- | Author: Lawrence H. Lash
- | Publisher: Humana
- | Publication Date: Nov 09, 2010
- | Number of Pages: 388 pages
- | Binding: Paperback or Softback
- | ISBN-10: 1617374946
- | ISBN-13: 9781617374944
