Overview
This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.
- | Author: Robert Doran
- | Publisher: Springer
- | Publication Date: Oct 15, 2016
- | Number of Pages: 202 pages
- | Binding: Paperback or Softback
- | ISBN-10: 3319370340
- | ISBN-13: 9783319370347
