A Silent Threat : Exploring New Therapies for Abdominal Aortic Aneurysms

Fibronectin (FN) is a component of the interstitial ECM. It also mediates cell attachment and function [16]. It is a ?bril-forming glycoprotein which is structurally a dimer of two identical proteins of 250 kDa covalently attached via disul?de bonds at their C termini. It is ubiquitously expressed in tissues. Different functional motifs on its structure helps fibronectin to interact with GAGs, collagens, ?brin and integrins facilitating matrix organization and cell-matrix interactions [18]. For example, ?bronectin serves as a template for proper collagen ?brillogenesis by forming a ?bril network engaged by cell surface integrins [16]. Cellular traction force causes FN to be stretched several times over its resting length [18]. As a result of such stretching, cryptic integrin-binding sites within the FN molecule is exposed resulting in pleiotropic changes in cellular behavior [18]. Hence FN acts as an extracellular mechano-regulator in addition to its role in cell migration during development. Studies have also shown the implication of FN in cardiovascular diseases and tumor metastasis

• | Author: Mackil
• | Publisher: Tredition Gmbh
• | Publication Date: Jul 05, 2024
• | Number of Pages: NA pages
• | Language: English
• | Binding: Paperback
• | ISBN-10: 3384280075
• | ISBN-13: 9783384280077