Pharmaceutical Applications of Dendrimers (Micro and Nano Technologies)

Dendrimers are engineered nano-sized macromolecule with a high degree of molecular uniformity, narrow size distribution, tunable size, multivalency and high surface functionality. These favourable characteristics make dendrimers effective drug delivery carriers. As a result, dendrimers have demonstrated wide applicability in nanopharmaceuticals Pharmaceutical Applications of Dendrimers explores the applications of dendrimers in solubilisation of hydrophobic active ingredients, drug delivery, gene delivery, imaging, diagnosis and photodynamic therapy. Dendrimers have been successfully used as a solubility enhancer and drug delivery carrier. Dendrimer-based formulations have also been used for transfection or gene delivery. Diagnostic applications of dendrimers include MRI contrast agent and imaging of diseased areas. In addition, dendrimers such as PPI and PAMAM are reported to possess anti-inflammatory, antimicrobial and antiviral activities. In past five years, photosensitizers such as rose Bengal and protoporphyrin IX have also been delivered using PAMAM and PPI dendrimers for the treatment of cancer. These important and emerging uses are discussed here in detail. This book is an important research reference for those who want to learn more about the development of dendrimer-based solutions for drug delivery. Explores the role of dendrimers in the design of dendritic nanoplateforms for targeted drug and gene delivery systems Discusses the potential of dendrimers in preformulation and formulation development Addresses the clinical and regulatory challenges in the development of dendrimer-based formulations

• | Author: Hitesh Kulhari, Abhay Singh Chauhan
• | Publisher: Elsevier
• | Publication Date: Nov 15, 2019
• | Number of Pages: 398 pages
• | Language: English
• | Binding: Paperback
• | ISBN-10: 0128145277
• | ISBN-13: 9780128145272