Protein Interaction Networks

The analysis of protein-protein interactions is fundamental to the understanding of cellular organization, processes, and functions. Recent large-scale investigations of protein-protein interactions using such techniques as two-hybrid systems, mass spectrometry, and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein-protein interaction networks. The resulting large volume of protein-protein interaction data has posed a challenge to experimental investigation. This book provides a comprehensive understanding of the computational methods available for the analysis of protein-protein interaction networks. It offers an in-depth survey of a range of approaches, including statistical, topological, data-mining, and ontology-based methods. The author discusses the fundamental principles underlying each of these approaches and their respective benefits and drawbacks, and she offers suggestions for future research.

• | Author: Aidong Zhang
• | Publisher: Cambridge University Press
• | Publication Date: Apr 06, 2009
• | Number of Pages: 292 pages
• | Binding: Hardback or Cased Book
• | ISBN-10: 0521888956
• | ISBN-13: 9780521888950