Formulating Poorly Water Soluble Drugs (Aaps Advances In The Pharmaceutical Sciences Series, 50)

The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.

• | Author: Robert O. Williams III|Daniel A. Davis Jr.|Dave A. Miller
• | Publisher: Springer
• | Publication Date: Aug 26, 2022
• | Number of Pages: 705 pages
• | Language: English
• | Binding: Hardcover/Medical
• | ISBN-10: 3030887189
• | ISBN-13: 9783030887186