Regulation Of Membrane Na+K Atpase (Advances In Biochemistry In Health And Disease, 15)

Na+K ATPase or Na-pump ATPase, a member of ?P?-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it?s a- and ß- subunits. At present four different a- (a-1,a-2,a-3 and a-4) and three ß- (ß-1, ß-2, and ß-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+K ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+K ATPase is either mediated by changes in intracellular Na concentrations that directly affect the Na+pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+K ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of a- and ß- subunits leading to an increased expression in the level of Na+pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra ne domain adjacent to the isoform(s) of a-ß subunits of Na+K ATPase. Considering the extraordinary importance of Na+K ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled ?Regulation of Membrane Na+K ATPase? for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+K ATPase regulation in health and disease.

• | Author: Sajal Chakraborti, Naranjan S Dhalla
• | Publisher: Springer
• | Publication Date: Mar 27, 2019
• | Number of Pages: 447 pages
• | Language: English
• | Binding: Paperback
• | ISBN-10: 3319796720
• | ISBN-13: 9783319796727