Studies On The Synthesis Of Fused Primidine Derivatives

INTRODUCTION Pyrimidine Pyrimidine (1) is the trivial name for 1,3-diazine: two meta oriental CH units in benzene have been replaced by nitrogen atom. Pyrimidine has one axis of symmetry about the C2-C5 axis, it has three different pairs of bond lengths and four different bond angles. Accordingly in 1H and 13C-NMR spectra the 1H and 13C nuclei are found at three different chemical shifts. Biological activity of pyrimidines: Pyrimidine derivatives and heterocyclic annelated pyrimidines continue to attract great interest due to the wide variety of interesting biological activities and therapeutic applications [Segal et al., 1962][Cumming et al., 2004] such as anticonvulsant [Tripathi et al., 1981], analgesic [Pemmsin et al., 1988], antihypertensive [Cammito et al., 1990], antipyretic [Smith et al., 1964], antiviral [Balzarini et al., 2002], anti-inflammatory drugs [Nega et al., 1990], bactericidal [Mastafanova et al., 1982], fungicidal [Zhikhareva et al., 1976]. As well as, they are used in agriculture as pesticides [Tetsuo et al., 1987] and plant growth regulators [Shishoo and Jain, 1992].

• | Author: Wesam Shehab, Hussam Saad, Ahmed Mustapha
• | Publisher: Noor Publishing
• | Publication Date: Oct 04, 2019
• | Number of Pages: 52 pages
• | Language: English
• | Binding: Paperback
• | ISBN-10: 3330846771
• | ISBN-13: 9783330846777